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Choose the choice which would best replace the underlined part of the given sentence.

It is important that whatever else happens, these two factors should not be messed around with.

1. It is important that
2. It is a fact that
3. It should be urgently understood that
4. It should be understood that

D seems to be the correct answer.

Reason: Its an extract that tells that a person is addressing some other person(s). So addressing like ' it should be kept in mind that ' and 'it should be understood that' like phrases are more suitable for such things.
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