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Look at this series: F2, __, D8, C16, B32, ... What number should fill the blank?

Here the letters decrease by 1; the numbers are multiplied by 2.

$(F-1)(2\times2)=E4$

$(E-1)(4\times2)=D8$

$(D-1)(8\times2)=C16$

$(C-1)(16\times2)=B32$

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